EHT 1864

Overview

EHT 1864 is an inhibitor of Rac family small GTPases . EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The K d values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo. EHT 1864 dependently suppresses the release of migrasomes from podocytes induced by LPS, PAN, or HG.

Application

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Product Information

• Catalog No.: HY-16659
• CAS No.: 754240-09-0
• Molecular Formula: C25H29Cl2F3N2O4S
• Molecular Weight: 581.48
• Purity: 99.85%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (3.58 mM); Clear solution
• Availability: In-stock

Source

Original product source