Pan-RAS-IN-6

Overview

Pan-RAS-IN-6 (compound 24) is an inhibitor targeting DUSP6 , which reduces MAPK activation in the brain of the NCI-H1373-Luc model ( DUSP6 ), at the same time, it shows significant tumor growth inhibition and tumor regression effects in the NSCLC brain metastasis mouse model. Pan-RAS-IN-6 shows high selectivity and strong inhibitory effects, especially in KRAS mutation-related signaling pathways, demonstrating varying inhibitory activity against different KRAS mutants and interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.

Application

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Product Information

• Catalog No.: HY-168012
• CAS No.: 3054023-07-0
• Molecular Formula: C46H60N8O5S
• Molecular Weight: 837.08
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source