TrxR/EGFR-IN-1

Overview

TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib ( HY-50895 )-sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis . TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis . In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib ( HY-50895 )-resistant lung cancer .

Application

Products | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > TrxR | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-168492
• CAS No.: 3038386-42-1
• Molecular Formula: C24H24AuClFN6O2P
• Molecular Weight: 710.88
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source