SHP2-IN-33

Overview

SHP2-IN-33 (Compound D13) is an allosteric inhibitor of SHP2 with an IC 50 of 1.2 μM. In cellular studies, SHP2-IN-33 demonstrates antiproliferative activity with an IC 50 of 38 μM against Huh7 cells by arresting the G0/G1 cell cycle, promoting apoptosis ( Apoptosis ), and suppressing the MAPK signaling pathway. In an in vivo Huh7 xenograft mouse model, SHP2-IN-33 exhibits significant antitumor activity and favorable pharmacokinetics, including 54% oral bioavailability and a half-life of 10.57 hours. SHP2-IN-33 is a promising compound for studying tumor diseases associated with SHP2 .

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > SHP2 | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPKAPK2 (MK2)

Product Information

• Catalog No.: HY-168715
• CAS No.: 2894017-46-8
• Molecular Formula: C16H19Cl2N5S
• Molecular Weight: 384.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source