LC3B recruiter 2

Overview

LC3B recruiter 2 (34R) is an LC3B recruiter and a component of the autophagy-lysosome pathway degradation system ( ATTEC , Autophagy-Tethering Compounds), which directly binds to LC3B . LC3B recruiter 2 binds to CDK9 inhibitor SNS-032 ( HY-10008 ) through a linker, forming an ATTEC that targets the degradation of the CDK9 and Cyclin T1 complex (with inhibitory effects on both). Therefore, LC3B recruiter 2 exerts activity through the LC3B-dependent autophagy-lysosome pathway, interfering with the cell cycle of cancer cells, thus exhibiting antitumor activity.

Application

Products | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Atg8/LC3 | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-168892
• CAS No.: 380636-64-6
• Molecular Formula: C10H9ClN2O2
• Molecular Weight: 224.64
• Purity: 98.11%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source