JNK-1-IN-3

Overview

JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, c-Jun and c-Fos , in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity.

Application

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Product Information

• Catalog No.: HY-169021
• CAS No.: 3056388-71-4
• Molecular Formula: C19H17FN4O3
• Molecular Weight: 368.36
• Purity: 98.44%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 5 mg/mL (13.57 mM); Clear solution
• Availability: In-stock

Source

Original product source