CQ-16 is an orally active small molecule drug conjugate (SMDC) targeting prostate-specific membrane antigen ( PSMA ). CQ-16 exhibits highly selective antiproliferative activity between PSMA -positive and PSMA -negative prostate cells. In addition, CQ-16 also has PARP inhibitory activity ( IC 50 =1 nM). (Pink: PSMA Ligand ( HY-139840 ); Black: Linker ( HY-W037980 ); Blue: PARP Inhibitor ( HY-10162 ))
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