TRAP-1

Overview

TRAP-1 (XJZ-06-462) is a transcriptional activator of p53 (TRAP) with JQ-1 carboxylic acid ( HY-78695 ) as its target protein ligand. TRAP-1 forms a ternary complex with p53 Y220C and BRD4 , potently activates p53 transcription, and inhibits the growth and proliferation of tumor cells. TRAP-1 upregulates p21 and other p53 target genes in pancreatic cell lines carrying p53 Y220C , and induces cellular senescence and apoptosis . TRAP-1 can be used in cancer research involving p53 Y220C -carrying tumors. (Pink: BRD4 ligand ( HY-78695 ); Blue: E3 ligase ligand; Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-169369
• CAS No.: 3109600-48-5
• Molecular Formula: C57H66ClF3N11O3PS
• Molecular Weight: 1108.69
• Purity: 99.69%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source