AP-1

Overview

AP-1 is a targeted ALK PROTAC degrader. AP-1 effectively degrades various ALK fusion/mutation forms, including degradation of NPM-ALK ( DC 50 = 4.6 nM) and EML4-ALK ( DC 50 = 357.6 nM), and exhibits a typical hook effect at high concentrations. AP-1 inhibits phosphorylation of downstream STAT3 , downregulates gene expression in the JAK-STAT pathway, and kills ALK -positive tumor cells via activating the caspase-3 -dependent apoptosis pathway. AP-1 shows cytotoxicity against a variety of cancer cells and possesses anti-tumor activity. AP-1 can be used in research related to non-small cell lung cancer , neuroblastoma, and anaplastic large cell lymphoma. (Pink: Anaplastic lymphoma kinase (ALK) ligand ( HY-169482 ); Blue: Cereblon ligand ( HY-10984 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Neuroblastoma | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy

Product Information

• Catalog No.: HY-169481
• CAS No.: 3027918-96-0
• Molecular Formula: C39H40ClN9O8S
• Molecular Weight: 830.31
• Purity: 97.8%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source