Topoisomerase I/II inhibitor 8

Overview

Topoisomerase I/II Inhibitor 8 ( Compound Ru7 ) is a dual catalytic inhibitor of Topoisomerase I/II , capable of inducing DNA damage and PARP-1 activation, which subsequently leads to the activation of RIPK1 , RIPK3 , and MLKL , ultimately triggering necroptosis . Topoisomerase I/II Inhibitor 8 demonstrates remarkable anticancer activity by effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis , showing great clinical potential in circumventing drug resistance in cancer treatment.

Application

Products | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Mixed Lineage Kinase | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Necroptosis | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > RIP kinase

Product Information

• Catalog No.: HY-169509
• CAS No.: 355400-87-2
• Molecular Formula: C14H11Br2NO5S2
• Molecular Weight: 497.18
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source