2-(Cyclohexylmethyl)-plumbagin

Overview

2-(Cyclohexylmethyl)-plumbagin is a derivative of the naphthoquinone compound Plumbagin ( HY-N1497 ). Under nutrient-deprived conditions, 2-(Cyclohexylmethyl)-plumbagin selectively exhibits cytotoxicity against PANC-1 human pancreatic cancer cells ( PC 50 = 0.11 µM) and reduces the phosphorylation of Akt and mTOR in PANC-1 cells. 2-(Cyclohexylmethyl)-plumbagin also induces apoptosis ( Apoptosis ) in PANC-1 cells at a concentration of 1 µM. Additionally, 2-(Cyclohexylmethyl)-plumbagin reduces tumor volume and weight in a xenograft MiaPaCa-2 pancreatic cancer mouse model.

Application

Products | Products > Signaling Pathways > Others | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-169830
• CAS No.: 3033734-59-4
• Molecular Formula: C17H18O3
• Molecular Weight: 270.32
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source