p53 Activator 14

Overview

p53 Activator 14 (Compound 7A) is a derivative of Neratinib ( HY-32721 ), that induces DNA damage, activates p53 , and inhibits the proliferation of multi cancer cells ( IC 50 =7.21 μM for HCT116 cell). p53 Activator 14 inhibits the adhesion, migration and invasion of HCT116, arrests the cell cycle, and induces apoptosis . p53 Activator 14 inhibits angiogenesis and exhibits antitumor efficacy in chick chorioallantoic membrane (CAM) model.

Application

Products | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-170591
• CAS No.: 2922588-44-9
• Molecular Formula: C28H29ClN4O3
• Molecular Weight: 505.01
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source