M3686

Overview

M3686 (Compound 29) is a potent, selective TEAD1 inhibitor with an IC 50 value of 51 nM. M3686 also shows weaker binding activity on TEAD3 . M3686 potently inhibits cell viability against YAP-dependent NCI-H226 cell line with an IC 50 value of 0.06 uM. M3686 shows strong anti-tumor effects in the NCI-H226 xenograft model.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > YAP

Product Information

• Catalog No.: HY-170764
• CAS No.: 2738550-24-6
• Molecular Formula: C21H18F3N5O2
• Molecular Weight: 429.40
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source