MU1409

Overview

MU1409 is an inhibitor of MRE11 nuclease with an IC 50 of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1 , with IC 50 values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Endonuclease

Product Information

• Catalog No.: HY-170845
• CAS No.: 2379671-78-8
• Molecular Formula: C20H14BrN3O3S
• Molecular Weight: 456.31
• Purity: 98.52%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (2.19 mM); Clear solution
• Availability: In-stock

Source

Original product source