Topo I/II-IN-2

Overview

Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II . Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC 50 s of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis , mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer ) cell proliferation, invasion, and migration in vitro. .

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > ROS Kinase

Product Information

• Catalog No.: HY-170912
• CAS No.: 3072844-85-7
• Molecular Formula: C25H26N2O4
• Molecular Weight: 418.48
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source