SGK1-IN-6 is a selective SGK1 inhibitor with an IC 50 of 0.39 μM, showing selectivity over SGK2 / 3 . SGK1-IN-6 inhibits cancer cell migration and invasion, improves SGK1 protein thermal stability. SGK1-IN-6 decreases SGK1 protein levels in tumor tissues, suppresses tumor growth in mouse xenograft models. SGK1-IN-6 can be used for the research of prostate cancer .
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