AF615

Overview

AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex ( IC 50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a K i = 0.37 μM in case of Geminin-tCDT1 interaction and a K i = 0.75 μM in case of Geminin-miniCDT1 interaction.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-171180
• CAS No.: 122510-61-6
• Molecular Formula: C10H13N5O2S
• Molecular Weight: 267.31
• Purity: 99.55%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source