CHK1-IN-12

Overview

CHK1-IN-12 (Compound example 1-5) is an orally active and highly selective checkpoint kinase 1 ( CHK1 ) inhibitor with in vitro enzyme IC 50 ≤10 nM and cellular IC 50 ≤50 nM. CHK1-IN-12 inhibits the phosphorylation activity of CHK1 kinase to block the DNA damage response pathway, inducing tumor cell cycle arrest and apoptosis . CHK1-IN-12 is promising for research of cancers.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Checkpoint Kinase (Chk) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-171785
• CAS No.: 2871056-82-3
• Molecular Formula: C19H19N7O2
• Molecular Weight: 377.40
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source