COX-2-IN-55

Overview

COX-2-IN-55 (compound 1) is an orally active, Celecoxib ( HY-14398 )-based analog with broad-spectrum anticancer activity and weak COX-2 inhibition. COX-2-IN-55 specifically inhibits SERCA2, increases caspase-3 cleavage and DR5 levels, thereby activating GRP78 and inhibiting the development of triple-negative breast cancer (TNBC). COX-2-IN-55 can also downregulate the levels of angiogenic markers VEGF-α and IL-8 , inhibiting the formation of microvessels.

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-171992
• CAS No.: 2649115-80-8
• Molecular Formula: C24H21F3N4O2S
• Molecular Weight: 486.51
• Purity: 99.20%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source