HDAC11-IN-2

Overview

HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 ( HDAC11 ) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC 50 s of 51.1 ×10 -3 μM and 5 μM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at Thr172 through the inhibition of HDAC11 , consequently modulating DNL and fatty acid oxidation in the liver.

Application

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Product Information

• Catalog No.: HY-172157
• CAS No.: 2919766-97-3
• Molecular Formula: C25H35N3O3
• Molecular Weight: 425.56
• Purity: 99.52%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 5 mg/mL (11.75 mM); Clear solution
• Availability: In-stock

Source

Original product source