PD-L1/HDAC6-IN-1

Overview

PD-L1/HDAC6-IN-1 is an orally active dual inhibitor of PD-L1 and HDAC6 , with IC 50 values of 26.8 nM and 78 nM, respectively. PD-L1/HDAC6-IN-1 binds to human and murine PD-L1 proteins with high affinity, while it reduces STAT3 phosphorylation and downregulates PD-L1 expression by inhibiting HDAC6 , thus blocking the PD-1/PD-L1 interaction. PD-L1/HDAC6-IN-1 exhibits potent anti-tumor activity in a mouse melanoma model. PD-L1/HDAC6-IN-1 is suitable for research on tumor immune regulation related to melanoma.

Application

Products | Products > Disease Areas > Cancer Immunology | Products > Disease Areas > Immunotherapy for Melanoma | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Melanoma | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PD-1/PD-L1 | Products > Signaling Pathways > HDAC

Product Information

• Catalog No.: HY-172200
• CAS No.: 2834094-36-7
• Molecular Formula: C27H33N3O3
• Molecular Weight: 447.57
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source