GSK-3α/β-IN-1

Overview

GSK-3α/β-IN-1 is GSK-3α/β inhibitor with IC 50 s of 0.265 μM and 0.255 μM for GSK-3α and GSK-3β , respectively. GSK-3α/β-IN-1 also inhibits PKA with an IC 50 of 0.188 μM. GSK-3α/β-IN-1 potently inhibits cell viability of three Glioblastoma (GBM) cell lines ( IC 50 : 3-6 μM, 72 h) with no toxicity to human astrocytes and good metabolic stability. GSK-3α/β-IN-1 has potential CNS activity in all-human blood-brain barrier (BBB) model of GBM.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > GSK-3 | Products > Signaling Pathways > PKA

Product Information

• Catalog No.: HY-172586
• CAS No.: 1574354-24-7
• Molecular Formula: C21H17N3O2
• Molecular Weight: 343.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source