TDO-IN-2

Overview

TDO-IN-2 (Compound 5c) is an orally active TDO inhibitor ( IC 50 : 1.25 μM). TDO-IN-2 has antitumor activity in the Hepa1-6 hepatocellular carcinoma allograft mouse model. TDO-IN-2 has synergistic effects with the PD-1/PD-L1 inhibitor BMS-202 ( HY-19745 ) and can be used to study tumor immune tolerance.

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Indoleamine 2,3-Dioxygenase (IDO)

Product Information

• Catalog No.: HY-172874
• CAS No.: 849458-55-5
• Molecular Formula: C20H15N3O3
• Molecular Weight: 345.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source