PI3K-IN-58

Overview

PI3K-IN-58 (Compound 17f) is a PI3Kα inhibitor ( IC 50 : 0.039 μM). PI3K-IN-58 exhibits significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231 and MDA-MB-453 cell lines with IC 50s of 3.48 μM, 1.06 μM, 2.21 μM and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression levels of anti-apoptotic proteins Bcl-XL and Bcl-2 and upregulating the expression of anti- apoptosis protein BAX . PI3K-IN-58 can be used in PI3K-targeted cancer research.

Application

Products | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-172886
• CAS No.: 3067572-78-2
• Molecular Formula: C22H22N6O3S
• Molecular Weight: 450.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source