Nedisertib (GMP)

Overview

Nedisertib (GMP) (Peposertib (GMP)) is Nedisertib ( HY-101570 ) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Nedisertib is an orally active selective DNA-dependent protein kinase ( DNA-PK ) inhibitor with an IC 50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2 , capable of reversing ABCG2 -mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity.

Application

Products | Products > GMP Small Molecules | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Signaling Pathways > DNA-PK | Products > Signaling Pathways > BCRP

Product Information

• Catalog No.: HY-101570G
• CAS No.: 1637542-33-6
• Molecular Formula: C24H21ClFN5O3
• Molecular Weight: 481.91
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source