GPV0057

Overview

GPV0057 (Compound 5d) is a selective and potent P-glycoprotein ( P-gp ) inhibitor. GPV0057 is also a selective potassium channel K ir 2.1 activator. GPV0057 competitively binds to the substrate-binding site of P-gp, inhibiting ATP-dependent drug efflux to reverse multidrug resistance in tumor cells. GPV0057 can also stabilizes the open state of K ir 2.1 and promotes potassium ion influx. GPV0057 is promising for research of tumors with high P-gp expression, K ir 2.1-deficient diseases such as heart failure and Andersen-Tawil Syndrome.

Application

Products | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Ovarian Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > P-glycoprotein | Products > Signaling Pathways > Potassium Channel

Product Information

• Catalog No.: HY-173162
• CAS No.: 86383-89-3
• Molecular Formula: C22H27NO4
• Molecular Weight: 369.45
• Purity: 99.20%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (13.53 mM); Clear solution
• Availability: In-stock

Source

Original product source