PLK1-IN-13

Overview

PLK1-IN-13 is a selective and orally active PLK1 inhibitor ( IC 50 : 0.27 nM). PLK1-IN-13 also inhibits PLK2 (IC 50 : 12.72 nM) and PLK3 (IC 50 : 4.12 nM). PLK1-IN-13 arrests cell at G2 phase, induces apoptosis and down-regulates the transcription of the proliferation-related oncogene c-MYC . PLK1-IN-13 inhibits tumor growth, and can be used for research of acute myeloid leukemia (AML).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-173212
• CAS No.: 3038489-48-1
• Molecular Formula: C29H39N9O2S
• Molecular Weight: 577.74
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source