Galectin-3-IN-6 is a human and murine galectin-3 ( Gal-3 ) inhibitor, with an IC 50 of 12 nM against human galectin-3 , an IC 50 of 12.6 nM against mutant murine galectin-3 (V160A), and a K d of 13 nM for human galectin-3 , as well as oral bioavailability. Galectin-3-IN-6 reduces the levels of liver fibrosis markers type I collagen and α-smooth muscle actin in mouse models of acute liver injury and fibrosis. Galectin-3-IN-6 can be used for the research of acute liver injury and fibrosis.
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