JV8

Overview

JV8 is a BRD4 PROTAC degrader. JV8 promotes the ubiquitination and degradation of BRD4 and induces apoptosis . JV8 has antitumor activity in a mouse 4T1 orthotopic tumor model. (Pink: BRD4 ligand ( HY-78695 ); Blue: E3 ligase VHL ligand ( HY-173435 ); Black: Linker ( HY-33366 ); E3 ligase VHL ligand-linker conjugate ( HY-173436 )).

Application

Products | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-173433
• CAS No.: 2841716-61-6
• Molecular Formula: C50H62ClN9O8S2
• Molecular Weight: 1016.67
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source