ST6GAL1-IN-1

Overview

ST6GAL1-IN-1 is an orally active selective ST6GAL1 inhibitor ( IC 50 = 20 μM). ST6GAL1-IN-1 exhibits high antimetastatic potential, effectively inhibiting the migration of MDA-MB-231 cells at noncytotoxic concentrations. ST6GAL1-IN-1 can disrupt integrin sialylation in MDA-MB-231 cells. ST6GAL1-IN-1 inhibits tumor angiogenesis and cancer metastasis via the Integrin / VEGFR2 -mediated signaling pathway. ST6GAL1-IN-1 effectively suppresses both tumor growth and cancer metastasis on the MDA-MB-231 xenograft model. ST6GAL1-IN-1 can be used for the study of Triple-negative breast cancer (TNBC).

Application

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Product Information

• Catalog No.: HY-173496
• CAS No.: 192876-13-4
• Molecular Formula: C35H50N2O4
• Molecular Weight: 562.78
• Purity: 99.33%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (1.78 mM); Clear solution
• Availability: In-stock

Source

Original product source