RMC-5127

Overview

RMC-5127 is a small molecule inhibitor that binds to GTP-targeted KRAS G12V , with oral bioavailability and blood-brain barrier permeability. RMC-5127 inhibits the activities of the RAS and MAPK pathways, suppresses the proliferation of KRAS G12V -mutant cancer cells and induces their apoptosis . RMC-5127 can be used for the research of KRAS G12V -mutant non-small cell lung cancer , pancreatic ductal adenocarcinoma, colorectal cancer and intracranial KRAS G12V tumors.

Application

Products | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Pancreatic Ductal Adenocarcinoma | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ras | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-173629
• CAS No.: 3082166-76-2
• Molecular Formula: C57H75N9O9S
• Molecular Weight: 1062.33
• Purity: 99.96%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.35 mM); Clear solution
• Availability: In-stock

Source

Original product source