AMG410

Overview

AMG410 is a non-covalent and selective pan- KRAS inhibitor with IC 50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 shows greater than 100-fold selectivity against both HRAS and NRAS. AMG410 is a dual GTP(on)- and GDP(off)-state inhibitor (K d (GDP-state) of 1 nM; K d (GTP-state) of 22 nM). AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. AMG410 can be used for the study of colorectal, pancreatic, and lung cancers.

Application

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Product Information

• Catalog No.: HY-173632
• CAS No.: 3040175-17-2
• Molecular Formula: C31H32ClF2N7O5
• Molecular Weight: 656.08
• Purity: 99.75%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source