EZH2-IN-23

Overview

EZH2-IN-23 (Compound 25) is an EZH2 inhibitor that exhibits potent enzymatic inhibition of the PRC2 complex ( EZH2 , EED, SUZ12, AEBP2, RbAp48) with a biochemical IC 50 of 0.8 nM. EZH2-IN-23 inhibits H3K27 trimethylation in cellular assays, showing an IC 50 of 40 nM. EZH2-IN-23 displays good rat PKproperties with 100 % oral bioavailability.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-174372
• CAS No.: 3095068-20-2
• Molecular Formula: C29H35ClN4O2S
• Molecular Weight: 539.13
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source