SF-9-2

Overview

SF-9-2 is a PD-L1/PD-1 binding inhibitor ( IC 50 = 24.9 nM). SF-9-2 inhibits epithelial-mesenchymal transition, migration, invasion, and proliferation of SK-N-SH cells, and also induces apoptosis and cell cycle arrest. SF-9-2 blocks PD-L1-induced SK-N-SH cell growth through the MAPK signaling pathway. SF-9-2 restores GSK-3β activity and enhances PD-L1 degradation through the ubiquitin-proteasome pathway. SF-9-2 inhibits tumor growth in the SK-N-SH NOG mouse model without significant toxicity. SF-9-2 also acts as an immune checkpoint inhibitor, blocking PD-L1 to restore T cell function. SF-9-2 can be used in neuroblastoma research.

Application

Products | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > ERK | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Cadherin | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > GSK-3 | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > PD-1/PD-L1 | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-175236
• CAS No.: 3053768-78-5
• Molecular Formula: C30H27F2N3O3
• Molecular Weight: 515.55
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source