SMI-10B13

Overview

SMI-10B13 is an Oncostatin M ( OSM ) inhibitor with a K D of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines ( IC 50 = 136 and 164 nM, respectively). SMI-10B13 shows anti-tumor effect in human breast cancer mice models.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-175465
• CAS No.: 3108487-29-9
• Molecular Formula: C23H16N2O3
• Molecular Weight: 368.38
• Purity: 99.30%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.79 mM); Clear solution
• Availability: In-stock

Source

Original product source