A2AAR antagonist 4 is an orally active A 2A Adenosine receptor antagonist with a K i of 0.36 nM and a K B of 1 nM at hA 2A AR. A2AAR antagonist 4 fully inhibits hA 2A AR and hA 2b AR at 10 μM. A2AAR antagonist 4 can be used for research of cancer , such as MC38 tiumor.
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