(E)-Belizatinib

Overview

(E)-Belizatinib ((E)-TSR-011)) (compound 36), the (E)-isomer of Belizatinib ( HY-17603 ), is a potent, selective and orally active anaplastic lymphoma kinase ( ALK ) Inhibitor with an enzymatic IC 50 of 0.005 μM and a cellular IC 50 of 0.048 μM. (E)-Belizatinib shows >61-fold selectivity over JAK2 , SRC , and IGF1R . (E)-Belizatinib shows favorable potency and PK characteristics in rats and dogs. (E)-Belizatinib can be used for ALK-driven cancer research.

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Anaplastic lymphoma kinase (ALK)

Product Information

• Catalog No.: HY-17603A
• CAS No.: 1388225-72-6
• Molecular Formula: C33H44FN5O3
• Molecular Weight: 577.73
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source