RG-12525

Overview

RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes , LTC4 , LTD4 and LTE4 , inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC 50 s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma ( PPAR-gamma ) agonist with IC 50 of appr 60 nM and a potent inhibitor of CYP3A4 , with a K i value of 0.5 µM.

Application

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Product Information

• Catalog No.: HY-101676
• CAS No.: 120128-20-3
• Molecular Formula: C25H21N5O2
• Molecular Weight: 423.47
• Purity: 98.31%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.91 mM); Clear solution
• Availability: In-stock

Source

Original product source