MBL-II-141

Overview

MBL-II-141 is potent ABCG2 inhibitor with an IC 50 of 0.11 μM. MBL-II-141 inhibits the transport function of ABCG2 in a non-competitive manner, preventing ABCG2 from pumping substrates (such as Irinotecan ( HY-16562 )) out of the cells, thereby increasing the accumulation of drugs within the cells. MBL-II-141 has no effect on ABCB1 (P-gp) and ABCC1 (MRP1) and has extremely low cytotoxicity ( IG 50 > 100 μM). MBL-II-141 can be used for the study of multidrug resistance (MDR) cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > BCRP

Product Information

• Catalog No.: HY-17648
• CAS No.: 1353747-12-2
• Molecular Formula: C28H23BrN2O5
• Molecular Weight: 547.40
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source