GPX4-IN-17

Overview

GPX4-IN-17 (Compound 9i) is an inhibitor of GPX4 with potent cytotoxicity ( IC 50 = 0.3 nM). GPX4-IN-17 shows strong binding affinity against GPX4 ( K D = 20.4 nM). GPX4-IN-17 inhibits tumor growth in the xenograft tumor mouse model without detectable cytotoxicity. GPX4-IN-17 can enhance cancer chemotherapy and overcome tumor resistance. GPX4-IN-17 can be studied in antitumor reseach.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Glutathione Peroxidase

Product Information

• Catalog No.: HY-176758
• CAS No.: 3035800-33-7
• Molecular Formula: C29H24N4O3S2
• Molecular Weight: 540.66
• Purity: 98.1%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source