Legubicin

Overview

Legubicin (Doxorubicin-LNAA-Boc) is a novel conjugate of Doxorubicin ( HY-15142A ) and a Legumain-cleavable peptide linker. Legubicin is activated by Legumain to release leucine-doxorubicin while sparing normal tissues. Legubicin inhibits tumor cell growth and reduces DNA binding in non-legumain expressing cells. Legubicin completely arrests tumor growth in mice bearing CT26 tumors. Legubicin can be used for the study of colon carcinoma (CRC).

Application

Products | Products > Signaling Pathways > Others | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Drug Derivative

Product Information

• Catalog No.: HY-176806
• CAS No.: 606967-53-7
• Molecular Formula: C48H64N6O18
• Molecular Weight: 1013.05
• Purity: 98.01%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source