VVD-442

Overview

VVD-442 is an inhibitor targeting PI3Kα . VVD-442 covalently binds to Cys242 in the RAS-binding domain of PI3K p110α, induces conformational changes, and disrupts the interaction between PI3K p110α and RAS proteins. VVD-442 also blocks RAS-mediated PI3K activation. VVD-442 can be used in research related to RAS-mutant cancers and HER2-overexpressing cancers.

Application

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Product Information

• Catalog No.: HY-176811
• CAS No.: 3055318-88-9
• Molecular Formula: C23H25BrClFN2O5S2
• Molecular Weight: 607.94
• Purity: 99.97%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: 2.5 mg/mL (4.11 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source