PNR-3-80

Overview

PNR-3-80 is an endonuclease G ( ENDOG ) inhibitor with an IC 50 of 0.67 μM. As a non-competitive binder to the ENDOG -substrate complex, PNR-3-80 specifically inhibits the endonuclease activity of ENDOG . PNR-3-80 reduces cell death induced by Cisplatin ( HY-17394 ) and Docetaxel ( HY-B0011 ), and inhibits DNA damage and autophagy ( autophagy ) induced by Etoposide ( HY-13629 ). PNR-3-80 can be used in studies related to cell injury.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Endonuclease | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-176835
• CAS No.: 1424353-63-8
• Molecular Formula: C24H14ClN3O3S
• Molecular Weight: 459.90
• Purity: 99.98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source