PI3K/mTOR-IN-18

Overview

PI3K/mTOR-IN-18 (Compound 12) is a highly selective dual PI3K / mTOR inhibitor. PI3K/mTOR-IN-18 shows antitumor effects via competitive binding to PI3Kα ( K i =0.130 nM) and mTOR ( K i =0.111 nM). PI3K/mTOR-IN-18 blocks the PI3K/AKT/mTOR pathway and inhibits tumor cell proliferation ( IC 50 =144 nM). PI3K/mTOR-IN-18 is promising for research of solid tumors (e.g., breast, NSCLC).

Application

Products | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > mTOR

Product Information

• Catalog No.: HY-176854
• CAS No.: 1220699-39-7
• Molecular Formula: C22H23N5O3
• Molecular Weight: 405.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source