LATS-IN-2

Overview

LATS-IN-2 is an efficiently acting LATS (large tumor suppressor kinase) inhibitor. LATS-IN-2 shows potent inhibitory activity against LATS1 with an IC 50 value of 1.3 nM. LATS-IN-2 suppresses the phosphorylation of YAP by inhibiting LATS kinase activity. LATS-IN-2 increases the thickness of the epidermis in mice. LATS-IN-2 can be used for the study of ocular diseases such as limbal stem cell deficiency and corneal endothelial dysfunction.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Others | Products > Signaling Pathways > Large Tumor Suppressor (LATS) | Products > Signaling Pathways > YAP

Product Information

• Catalog No.: HY-176886
• CAS No.: 2248728-49-4
• Molecular Formula: C15H16N6
• Molecular Weight: 280.33
• Purity: 99.45%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (8.92 mM); Clear solution
• Availability: In-stock

Source

Original product source