Tubulin-IN-51

Overview

Tubulin-IN-51 is an orally available, potent tubulin inhibitor ( IC 50 = 31 nM). Tubulin-IN-51 promotes tubulin polymerization in vitro and does not compete with Paclitaxel ( HY-B0015 ) for binding. Tubulin-IN-51 inhibits the binding of Vinblastine ( HY-13780 ) to tubulin. Tubulin-IN-51 downregulates the proportion of cells in the G1 phase and induces apoptosis . Tubulin-IN-51 inhibits tumor growth in multiple nude mouse xenograft models.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-177021
• CAS No.: 849550-36-3
• Molecular Formula: C18H18ClF5N6O
• Molecular Weight: 464.82
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source