Faridoxorubicin (AVA-6000) is a prodrug targeting fibroblast activation protein α ( FAPα ). Faridoxorubicin releases active doxorubicin through FAPα-mediated cleavage, enhancing intratumoral drug exposure and reducing cardiac toxicity. Faridoxorubicin is promising for research of solid tumors (e.g., colorectal cancer liver metastasis).
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