AGF347

Overview

AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase ( SHMT ) 2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis , inhibits mTOR signaling, decreases GSH pools, and increases ROS . AGF347 inhibits proliferation of Cisplatin ( HY-17394 ) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > Antifolate | Products > Signaling Pathways > SHMT

Product Information

• Catalog No.: HY-177092
• CAS No.: 2294820-23-6
• Molecular Formula: C22H24FN5O6
• Molecular Weight: 473.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source