Mesutoclax

Overview

Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC 50 of 1.54 nM. Mesutoclax has weak activity against BCL-XL ( IC 50 : ＞1000 nM). Mesutoclax can inhibit the activity of RS4;11 cells with an IC 50 of 2.75 nM. Mesutoclax can be used in the study of cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family

Product Information

• Catalog No.: HY-177102
• CAS No.: 2760536-87-4
• Molecular Formula: C45H50ClN7O8S
• Molecular Weight: 884.44
• Purity: 98.69%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.83 mM); Clear solution
• Availability: In-stock

Source

Original product source