HPK1-IN-61 (Compound 1) is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) ( K i = 0.4 nM) and an inhibitor of Abl ( IC 50 < 0.51 nM). HPK1-IN-61 also shows inhibitory activity against LCK with an IC 50 of 24 nM.
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